STUDY OF CHRONIC KIDNEY DISEASE AND ANEMIA IN CHRONIC OBSTRUCTIVE PULMONARY DISEASE (COPD) PATIENTS

Abstract

The relation between chronic obstructive pulmonary disease (COPD) and
chronic kidney disease (CKD) has been largely undescribed and the occurrence
and frequency of anemia in COPD has rarely been studied, so the aim of this
study is: to estimate the frequency of undiagnosed CKD among COPD patients
and to verify whether concealed CKD is prevalent in COPD population, and to
assess the frequency of anemia in COPD patients and its relation to the severity
of the disease. Patients and methods: this study included 100 stable COPD
patients with various degrees of severity. They were divided into 2 groups:
group (І): patients with mild to moderate severity of COPD (n=43) and group
(П): patients with severe to very severe COPD (n= 57). All studied patients
were subjected to: pulmonary function tests, complete blood count,
erythropoietin level measurement, glomerular filtration rate measurement, and
arterial blood gases analysis. Results: there was a statistically non- significant
increased frequency of concealed chronic renal failure (CRF) in patients of
group (П) than that of group (І). But a significant increased frequency was seen
in overt CRF in patients of group (П) than that of group (І) with a statistically
significant positive correlation between COPD severity and renal function
reduction . As regards the frequency of anemia, there was a statistically
significant high frequency of anemia in patients of group (П) than that of
group (І) with a statistically very highly significant negative correlation
between COPD severity and hemoglobin level. Conclusions: 1) CRF occurs in
high rates in COPD patients and it is related to the disease severity. 2) Anemia
is a frequent co-morbidity among COPD patients especially in those with
severe disease.
Key words: COPD, chronic kidney disease, anemia.